Armodafinil Vs. Modafinil: Differences, Interactions, and Side Effects

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Armodafinil and Modafinil are wakefulness-promoting agents with many similarities but differ in their brand names, efficacy, half-life, and chemical structure.

People suffering from narcolepsy, insomnia, or both require medication to stop their sleep in a variety of time. These medications are called wakefulness-promoting agents that promote the concentration of certain natural substances in the brain responsible for wakefulness.

Two of these are Armodafinil along with Modafinil. Both treat conditions such as Narcolepsy, shift working disorders, insomnia/hypopnea and so on. While both are related and have the same reason but they differ in couple of ways. This article will examine the differences among Armodafinil as well as Modafinil as well as their interaction as well as negative side effects.

Differences Between Armodafinil and Modafinil

Armodafinil and Modafinil share a range of similarities. However, there are some differences between the two. Let’s examine a few of these features.

Brand Name

The names of the brand names for the two medicines are different. Armodafinil is available under the trademark name Nuvigil, while Buy Modafinil Online is sold under the brand name Provigil.

Standard Dosage

The dosage for Armodafinil could be 150 mg per day and the dosage of Modafinil can be 200 mg per day. Both tablets are used to be consumed orally.

Chemical Structure

The primary distinction that is noticeable between Armodafinil in their structure chemically. It is the most significant difference is the chemical structure of Armodafinil in comparison to Modafinil. Armodafinil is a relatively new drug taken from the Modafinil family. It is the R-enantiomer Modafinil.


The half-life of drugs is how long the substance stays in your body, or how long it takes for your body to rid itself of it. In this way, Armodafinil has a longer half-life than Modafinil. Because of this, Armodafinil is often regarded as the stronger of the two and is believed to have more wakefulness-enhancing effects.


In terms of how effective they are, Armodafinil is more potent. It has longer-lasting effects than Modafinil. Both drugs are used to treat illnesses such as narcolepsy Obstructive sleep apnea, as well as other. They also serve as non-prescription treatment for cancer-related fatigue MS, multiple sclerosis, as well as mental disorders such as ADHD as well as depression.

Based on research, Armodafinil is shown to be more effective in reducing plasma concentrations later in the daytime. Due to these higher concentrations Armodafinil’s effectiveness is higher than Modafinil.


When prescribing medication, it’s important to consider its cost and how much the patient is able to afford. Armodafinil is considerably less expensive than Modafinil. A generic variant of Armodafinil could cost as little as $500. However, it can be bought for as little as $277, in it’s form in Armodafinil.

But, Modafinil costs over $600.

Side Effects of Armodafinil and Modafinil

As with all medicines Armodafinil and Modafinil are both associated with a variety of adverse effects. These adverse effects can be moderate or severe.

Here are some of the most often reported side effects associated with these medications:





Modafinil can trigger other symptoms, like:


Nasal congestion (rhinitis)


Back discomfort

Other adverse reactions that are typical of these two medications include:

Dry mouth

Indigestion (dyspepsia)


Weight loss

Appetite is reduced

The adverse side effects of Armodafinil as well as Modafinil are:

Allergies like breathing shortness and rashes

The psychological results of psychiatry can include depression and psychosis.

If you are suffering from common symptoms that can last lengthy periods or have extreme side effects, contact your doctor immediately and seek medical guidance.

Drug Interactions

Apart from the numerous differences, Armodafinil and Modafinil have the same interactions with prescription drugs. They may affect the way in which specific substances get processed inside the body, and this is due to the fact that they are stimulants for the CYP3A4 enzyme as well as inhibitors of the CYP2C19 enzyme.

The contraceptives that are most commonly used have become the most sought-after. Armodafinil and Modafinil may reduce the effectiveness of steroidal contraceptives including Ethinyl estradiol as well as norethindrone. They can trigger unexpected pregnancies for women who use these drugs and plan to get contraception in the same day. If you are currently taking Armodafinil and Modafinil and want to avoid pregnancy, you should think about an alternative method of contraception. It is a good idea to be considered in conjunction with the treatment of the drugs, and in the first month after stopping the medication.

In addition, Armodafinil and Buying Modafinil Online may enhance the clearance of cyclosporine which is an immunosuppressant that is found throughout the body. If you use any of these drugs in conjunction with cyclosporine, it could lower the effectiveness of cyclosporine.

Another interaction is CYP2C19 substrates like diazepam, omeprazole and diazepam, in addition to phenytoin and many others. Armodafinil and Modafinil decrease the removal from CYP2C19 substances from our bodies, which results in increased levels of drugs. Because of their increased levels they can cause negative effects and toxicities to CYP2C19 substrates.


Armodafinil and Modafinil are wakefulness-promoting agents used for narcolepsy and shift work disorder. Armodafinil (Nuvigil) as well as Modafinil (Provigil) are distinct brand names. Armodafinil is more potent and has longer duration to last and more powerful effects. It’s also usually less expensive than Modafinil. Both

A majority of medicines cause adverse consequences. They can cause serious side effects, and may cause allergic reactions as well as psychotic adverse effects. They’re like drug interactions that could reduce the effectiveness of contraceptives and alter the way they are cleared. Talk to your doctor for any serious adverse side effects and consider other methods of contraception when using these medications.

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